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The main responsibility of the hospitals discussed was patient care and data collection. Taichung Hospital presents the results. Interstitial cystitis patients in Taiwan have lower economic status but lower impact on QOL than Western patients. However, the sexual-related pain and sleeping disorder were higher than previously thought and deserve our attention. Accordingly, this research provides a foundation for further investigations of baseline associations and longitudinal trends.

Predictors of symptom severity in patients with chronic prostatitis and interstitial cystitis. However, few studies have been done to identify predictors of disease severity. Univariate and multivariate analyses were performed to identify characteristics predictive of worse symptoms.

The most commonly reported comorbidities were allergies, sinusitis, erectile dysfunction and irritable bowel syndrome in men, and allergies, urinary incontinence, sinusitis and irritable bowel syndrome in women. In the 2 sexes self-reported urinary frequency and urgency, worse depression scores and lower education level were independent predictors of worse symptom severity.

In men additional independent predictors were self-reported pelvic pain, fibromyalgia and previous heart attack, and in women an additional independent predictor was postmenopausal status. There are several common medical conditions associated with urological pelvic pain syndromes in men and women. Few of them were predictive of symptoms severity in this analysis.

Interstitial Cystitis. Doctors are not sure exactly why distension helps. It may make your bladder better able If you have muscle spasms, you can learn Lupus cystitis in Korean patients with systemic lupus erythematosus: risk factors and clinical outcomes.

This study was performed to investigate the clinical characteristics of lupus cystitis and determine the risk factors and clinical outcomes of lupus cystitis in patients with systemic lupus erythematosus SLE. We retrospectively reviewed patients at Seoul St. Mary's Hospital in Seoul, Korea, from to Twenty-four patients had lupus cystitis. Three-fourths of patients with lupus cystitis had concurrent lupus mesenteric vasculitis LMV.

The initial symptoms were gastrointestinal in nature for most patients High-dose methylprednisolone was initially administered to most patients Two patients 8. Sixty-five age- and sex-matched patients with SLE who were admitted with other manifestations were included as the control group. The median follow-up period was 3.

Complications developed in Our results suggest that the possibility of lupus cystitis should be considered when a patient with SLE and history of LMV presents with gastrointestinal symptoms or lower urinary tract symptoms. Development of complications in patients with lupus cystitis can be fatal.

Thus, intensive treatment. Interstitial cystitis - resources. Resources - interstitial cystitis The following organizations are good resources for information on interstitial cystitis : Interstitial Cystitis Association -- www.

Treatment of radiation cystitis with hyperbaric oxygen. A patient with severe radiation cystitis resistant to current therapy was treated with hyperbaric oxygen to facilitate closure of a vesicocutaneous fistula.

In addition to the fistula healing, her symptoms of radiation cystitis have not recurred for over a year and a half. Post-hoc comparisons were performed between the results of the KHQ of this study and a sample of patients with urinary incontinence UI. Results on RSES were analyzed with data from the general population and from patients with erectile dysfunction. High levels of deterioration in QoL were described: KHQ scores were significantly higher when compared with patients with UI P Cystitis present high levels of anxiety, and significant reductions in both quality of life and self-esteem.

Especially for men, this affectation is similar to that caused by erectile dysfunction. Published by Elsevier Espana. One hypothesis is that interstitial cystitis symptoms arise from increased bladder permeability to urine solutes. This study establishes the feasibility of using contrast enhanced magnetic resonance imaging to quantify bladder permeability in patients with interstitial cystitis. Permeability alterations in bladder urothelium were assessed by intravesical administration of the magnetic resonance imaging contrast agent Gd-DTPA Gd-diethylenetriaminepentaacetic acid in a small cohort of patients.

Magnetic resonance imaging signal intensity in patient and control bladders was compared regionally and for entire bladders. Data suggest that contrast enhanced magnetic resonance imaging provides an objective, quantifiable measurement. Interstitial cystitis intravesical therapy. Interstitial cystitis IC is a progressive bladder disorder that presents with symptoms of bladder urgency, frequency and pain. The aetiology of the disease remains uncertain, but it is postulated that there is an initial infective insult which damages the glycosaminoglycan GAG layer of the bladder urothelium.

This defect allows an influx of ions, particularly potassium, which initiates an inflammatory reaction in the bladder wall, which incites the symptoms described above. Treatment initially involves behavioural and oral medication, with second line being intravesical instillation therapy.

Treatment strategies focus on restoring lower urinary tract epithelial function, inhibiting neural activation, controlling allergies and relieving symptoms. In this review, current intravesical therapy will be discussed, as well as what lies on the horizon for intravesical therapy in IC.

Interstitial cystitis. Reduce or stop consuming caffeine, chocolate, carbonated beverages, citrus drinks, and foods with a Ketamine-snorting associated cystitis. Ketamine hydrochloride, commonly used as a pediatric anesthetic agent, is an N-methyl-D-aspartic NMDA acid receptor antagonist with rapid onset and short duration of action.

It produces a cataleptic-like state where the patient is dissociated from the surrounding environment by direct action on the cortex and limbic system. It has emerged as an increasingly popular choice among young drug users, especially within dance club venues. Cases of bladder dysfunction among recreational ketamine users were reported since Shahani et al first reported nine cases of ketamine-associated ulcerative cystitis in We report on four patients who had history of ketamine abuse, presenting with dysuria, fluctuating lower urinary tract symptoms LUTS , lower abdominal or perineal pain, and impaired functional bladder capacities.

Urinalysis showed pyuria and microhematuria. Urine culture was sterile. Bladder ulceration with severe diffuse hemorrhage and low bladder capacity were noted under anesthetized cystoscopic examination. Transurethral bladder mucosa biopsy was consistent with chronic cystitis. Cessation of ketamine abuse was the milestone of treatment, followed by the administration of mucosal protective agents, such as pentosan polysulphate or hyaluronic acid.

Suprapubic pain was improved in three patients during follow-up. However, the outcome of treatment depends on the severity of the disease process, similar to that of interstitial cystitis IC. Published by Elsevier B. We assessed the severity of pain, frequency, and urgency using Likert and categorical scales, and how often these symptoms were experienced using the ICSI.

We compared these scales by frequency distributions and interscale correlations. However, for urgency, the ICSI question of "the strong need to urinate with little or no warning" consistently yielded lower scores than the severity question of "the compelling urge to urinate that is difficult to postpone. Compared with the severity question, the ICSI underestimated the prevalence and degree of urgency. Advances in Therapeutic Development for Radiation Cystitis.

Radiation treatment for pelvic malignancies is typically associated with radiation injury to urinary bladder that can ultimately lead to radiation cystitis RC. The late sequelae of radiation therapy may take many years to develop and include bothersome storage symptoms such as hematuria, which may be life-threatening in severe cases of hemorrhagic cystitis.

Although no definitive treatment is currently available, various interventions are used for radiation and hemorrhagic cystitis including blood transfusion, bladder irrigation, intravesical instillation of substances such as alum, silver nitrate, prostaglandins or formalin, and fulguration of intravesical bleeding sites and surgery options such as supravesical urinary diversions and cystectomy. Effects of non-surgical treatments for radiation and hemorrhagic cystitis are of modest success and studies are lacking to control the effects caused by RC.

When such measures have proven ineffective, use of bladder botulinum toxin injection has been reported. New therapy, such as intravesical immunosuppression with local tacrolimus formulation is being developed for the treatment of radiation hemorrhagic cystitis. Severe emphysematous cystitis : Outcome after seven days of antibiotics. We present the case of a year-old woman with emphysematous cystitis. She was a diabetic patient and she was on chemotherapy treatment for a breast cancer.

She complaint of severe asthenia and pain in her right lower extremity, but no fever or urinary symptoms. A computed tomography CT scan was suggestive of severe emphysematous cystitis. Emphysematous cystitis is a rare clinically entity, more commonly seen in diabetic, immunocompromised patients. Hyperbaric oxygen: Primary treatment of radiation-induced hemorrhagic cystitis. Of 8 patients with symptoms of advanced cystitis due to pelvic radiation treated with hyperbaric oxygen 7 are persistently improved during followup.

All 6 patients treated for gross hematuria requiring hospitalization have been free of symptoms for an average of 24 months range 6 to 43 months. One patient treated for stress incontinence currently is dry despite little change in bladder capacity, implying salutary effect from hyperbaric oxygen on the sphincter mechanism. One patient with radiation-induced prostatitis failed to respond.

This experience suggests that hyperbaric oxygen should be considered the primary treatment for patients with symptomatic radiation-induced hemorrhagic cystitis. Narrow band imaging cystoscopy can increase the visualization and detection of Hunner's lesions. All typical Hunner's lesions and suspected areas identified by narrow band imaging were electrocoagulated endoscopically after the biopsy of those lesions.

Therapeutic efficacy was assessed prospectively by using visual analog scale score of pain, O'Leary-Sant's symptom index , O'Leary-Sant's problem index and overactive bladder symptom score. The mean follow-up period was 22 months. The average visual analog scale pain scores significantly decreased from 7. A total of 21 patients Daytime frequency was significantly decreased postoperatively.

O'Leary-Sant's symptom index , O'Leary-Sant's problem index and overactive bladder symptom score were significantly decreased postoperatively. However, during the follow-up period, a total of six patients had recurrence, and repeat narrow band imaging-assisted transurethral electrocoagulation of the recurrent lesions was carried out for five of the six patients, with good response in relieving bladder pain. There were no significant differences between the groups in answers to the other five questions of the BBDQ.

Further prospective studies are needed to further evaluate these novel findings. Purpose: In this prospective cohort study, the effects of hyperbaric oxygen treatment HBOT were evaluated concerning patient-perceived symptoms of late radiation-induced cystitis and proctitis secondary to radiation therapy for pelvic cancer. Methods and Materials: Thirty-nine patients, 35 men and 4 women with a mean age of 71 range, years were included after informed consent and institutional ethics approval.

Patients with hematuria requiring blood transfusion were excluded. Mean number of treatments was 36 The improvement was sustained at follow-up in both domains 6 to 12 months after HBOT. No severe side effects were observed related to HBOT, and treatment compliance was high.

Conclusions: HBOT can be an effective and safe treatment modality for late radiation therapy-induced soft tissue injuries in the pelvic region. Interstitial cystitis is the first cause of bladder pain. In case of failure of the usual treatments, several other modalities have been proposed. These therapeutic modalities are posterior sacral root neuromodulation, posterior tibial nerve stimulation, vanilloid agent intravesical instillation, intradetrusor botulinum toxin injections and surgery.

A certain efficiency of each of these treatments in the interstitial cystitis has been reported. However, the evaluation of these treatments is limited and the level of evidence is too low to propose these treatments in routine.

This study aimed to establish validity and reliability of the Filipino Reflux Symptom Index FRSI and to test it among patients with laryngopharyngeal reflux LPR before and after 6 months' trial of rabeprazole. A case-control study was carried out. Reliability, validity, and internal consistency were computed. A total of 58 participants, 29 patients and controls each, aged years completed the study. FRSI had good item-total correlations indicating psychometrically sound items.

There were significant differences between patients and controls for FRSI scores and mean scores. There were no significant differences between RFS 2 and 1. Initial response to a 2-week empirical proton pump inhibitor trial may support an impression of LPR; non-response warrants specialist referral for further investigation. The objective of the present study was to examine the joint effects of the body mass index and the MAOA gene polymorphism on depressive symptoms. In two independent Chinese samples, we measured adolescents' depressive symptoms and body mass index and collected their DNA.

The results indicated that the main effects of the MAOA gene polymorphism on depressive symptoms were significant. However, the main effects of body mass index and the interaction of the MAOA gene polymorphism and body mass index on depressive symptoms were not significant.

By using Chinese adolescents, this study confirmed that the MAOA gene polymorphism directly influenced adolescents' depressive symptoms. A total of 23 female patients completed the study. Patients received endovesical administration of hyaluronic acid and chondroitin sulfate in normal saline, 40 ml, weekly for 12 weeks and then bi-weekly for 6 months, if there was initial response.

The average number of voidings and mean voiding volumes revealed significant improvement after the 12 weeks' treatment period, with a significant reduction and increase, respectively. Mean voiding volume increased from ml to , which apparently was not reflected in a corresponding reduction of number of daily voids from 15,5 to VAS values decreased from 5,4 to 3,6 pain and from 6,0 to 3,5 urgency after the treatment cycle, showing a significant improvement.

METHODS Women from 18 to 49 years of age with symptoms of cystitis provided specimens of midstream urine, after which we collected urine by means of a urethral catheter for culture catheter urine. We compared microbial species and colony counts in the paired specimens. The primary outcome was a comparison of positive predictive values and negative predictive values of organisms grown in midstream urine, with the presence or absence of the organism in catheter urine used as the reference.

RESULTS The analysis of episodes of cystitis in women yielded paired specimens of midstream urine and catheter urine that could be evaluated. Among 41 episodes in which enterococcus, group B streptococci, or both were found in midstream urine, E. Funded by the National Institute of. Hemorrhagic cystitis : A challenge to the urologist. Severe hemorrhagic cystitis often arises from anticancer chemotherapy or radiotherapy for pelvic malignancies. Infectious etiologies are less common causes except in immunocompromised hosts.

These cases can be challenging problems for the urologist and a source of substantial morbidity and sometimes mortality for the patients. A variety of modalities of treatment have been described for the management of hemorrhagic cystitis but there is none that is uniformly effective.

Some progress has been made in the understanding and management of viral hemorrhagic cystitis. This article reviews the common causes of severe hemorrhagic cystitis and the currently available management options.

Objectives To investigate whether polyomaviruses contribute to interstitial cystitis pathogenesis. Subjects and Methods A prospective study was performed with 50 interstitial cystitis cases compared with 50 age-matched, disease-free controls for the frequency of polyomaviruria. Associations between polyomaviruria and disease characteristics were analysed in cases. Polyomavirus in urine and bladder tissue was detected with species JC virus vs.

BK virus specific, real-time PCR. There was a significant increase in the frequency of polyomavirus shedding between cases and controls p cystitis cases after adjustment for age and sex OR 6. There was a significant association among cases between the presence of BK viruria and response to intravesical Clorpactin therapy OR 4. Conclusion The presence of polyomaviruria was found to be associated with the ulcerative form of interstitial cystitis.

Clorpactin, which has anti-DNA virus activity, was more likely to improve symptoms in the presence of BK viruria. These data from this pilot study suggest associations between polyomaviruria and interstitial cystitis warranting further investigation.

Cystitis glandularis in a cat. An 8-year-old intact male Persian cat was presented for investigation of chronic haematuria. The cat had episodes of haematuria on several occasions that were non-responsive to antimicrobial therapy. Abdominal ultrasound examination revealed dilation of the renal pelvis and ureters of both kidneys. The urinary bladder wall was thickened, a mass of heterogeneous echogenicity filled the lumen of the bladder, and two parallel thin hyperechoic lines were identified within the lumen, which suggested a urethral catheter.

Differential diagnoses for the urinary bladder mass included cystitis and neoplasia. The mass was surgically removed from the urinary bladder, and a urethral catheter was found embedded in the mass. Histopathological findings were consistent with cystitis glandularis of a typical type. Periodic bladder ultrasonographic studies were performed; at the time of writing, over 2 years later, recurrence had not been detected. Long-term results of amitriptyline treatment for interstitial cystitis.

We performed a prospective, open label study to examine the safety and efficacy of the long-term administration of the tricyclic antidepressant amitriptyline in patients with interstitial cystitis IC. Amitriptyline was received strictly at bedtime following an established self-titration protocol without a limitation of the maximum daily dose. Patients reporting improvement in a global response assessment questionnaire were considered treatment responders.

Further efficacy measures were changes in pain and urgency, functional bladder capacity and frequency. Changes in the O'Leary-Sant IC index and rating of overall satisfaction with the therapeutic outcome were also reported. The overall mean dose was 55 mg range Improvement in the various IC symptoms was statistically significant compared with baseline. Long-term administration of amitriptyline is a feasible, safe and effective treatment for IC, provided that the drug is used judiciously to minimize adverse effects.

The therapeutic response to amitriptyline was uniformly observed in patients fulfilling NIDDK criteria and in those with the pure clinical diagnosis of IC. Case-control study of medical comorbidities in women with interstitial cystitis. We used physician assigned diagnoses in an electronic medical record to assess comorbidities associated with interstitial cystitis. A computer search of the administrative database at Kaiser Permanente Northwest, Portland, Oregon was performed for May 1, to April 30, All women with a medical record diagnosis of interstitial cystitis ICD-9 code These cases were then matched with 3 controls each based on age and duration in the health plan.

The medical diagnoses using ICD-9 codes restricted to 3 digits assigned to these 2 groups were compared using the OR. A total of cases and matched controls were analyzed. There were 23 diagnoses that were significantly more common in cases than in controls p symptoms. Additional specific conditions associated with interstitial cystitis were gastritis OR A diagnosis of interstitial cystitis was associated with multiple other unexplained physical symptoms and certain psychiatric conditions.

Studies to explore the possible biological explanations for these associations are needed. Eosinophilic cystitis with recurrent urinary retention: case report. Eosinophilic cystitis is a rare inflammatory disease of the bladder whose origin, pathogenesis, and treatment are unknown. Frequency, dysuria, and hematuria are frequent symptoms. Here, we report a rare occurrence of recurrent urinary retention and repetitive catheterization.

A year-old male presented with acute urinary retention and intermittent gross hematuria of 2 weeks duration. Urethral catheterization followed by a trial without catheter, was successful. Complete blood count showed presence of eosinophils eosinophilia and computed tomography of kidneys, ureter and bladder with contrast showed thickened bladder wall and small prostate. Cystoscopy revealed an erythematous lesion over the anterior wall. The rest of the mucosa was normal.

Transurethral biopsies of the lesion were performed and histologic examination showed features of eosinophilic cystitis. Despite multiple medication regimens containing corticosteroids and antihistamines, he presented with recurrent urinary retention, approximately once every month. After 6 months, he was started on bethanechol, which led to no catheterization for up to 2 years. To the best of our knowledge, this is the first report on the successful use of bethanechol as a treatment for eosinophilic cystitis with recurrent urinary retention.

The Interstitial Cystitis IC has been considered in the past an uncommon pathology, however it has received a special attention during the last 20 years, scientific articles published since to There are many therapeutic options not at all satisfactory because there isn't consensus about diagnostic and treatment.

To share our experiences in the treatment of interstitial cystitis , additionally, to comment on the therapeutic response of treatment used. The diagnosis was done in agreement with the concepts of Interstitial Cystitis group from clinical and cystoscopic characteristics. Fuermaier, Anselm B.

A bladder infection can be painful and annoying, Nighttime bed-wetting on its own isn' Incidence and clinical characteristics of interstitial cystitis in the community. We utilized physician-coded diagnoses and chart reviews to estimate the incidence of interstitial cystitis IC in women.

Chart reviews were performed and patient demographics, diagnosing physicians, and symptom characteristics were recorded. The IC incidence rate was 15 per , women per year. The mean age of the patients was 51 years range years. Cases diagnosed by primary care physicians had a shorter median symptom duration 9 months compared with those diagnosed by urologists 1 year and gynecologists 3 years.

IC is an uncommon diagnosis in the community setting, with an incidence rate of 15 per , women per year. Data were analyzed with univariate methods or multivariate logistic regression analysis accordingly. Mean age and duration of symptoms was A longer. Differences in initial symptom scores between myogenous TMD patients with high and low temporomandibular opening index. The temporomandibular opening index TOI is a more useful measure of mandibular movement than linear mouth opening, since it is independent of age, gender, ramus length, and gonial angle.

It is also useful when categorizing temporomandibular disorder TMD patients into diagnostic groups. Two subgroups of myogenous patients have been identified, one with a high and one with a low temporomandibular opening index. This study examined initial symptom severity in these two subgroups. Thirty-three 33 patients with a myogenous temporomandibular disorder were recruited. Twenty-six 26 were female and seven male. Eleven were found to be in the high temporomandibular opening index group and the remaining 22 in the low group.

Symptom severity scores were determined prior to the start of treatment. Pain, joint sounds, headache, and neck pain were all rated by patients on a four-point verbal response scale. These symptom scores were compared between the two subgroups using the Wilcoxon two sample test. TMD patients with high temporomandibular opening index appeared to have more severe signs and symptoms of TMD than patients with a low index.

The project is ongoing. Using population based screening methods, we applied these case definitions to determine the prevalence of these conditions in men. An initial men screened positive, of whom met the inclusionary criteria and completed the telephone interview.

These case definitions were used to classify subjects into groups based on diagnosis. Differences in the other primary symptoms associated with these conditions probably influence how urgency is perceived. There is a need for a brief symptom index for advanced kidney cancer that includes perspectives of both patients and clinicians and is consistent with the Food and Drug Administration's guidance for patient-reported outcome measures.

Fifty patients with advanced kidney cancer provided open-ended and survey responses ranking their most important symptoms. Responses were reconciled with published clinician reports of the most important symptoms. Ten experienced oncologists rated symptoms as disease- or treatment-related.

Patients completed quality-of-life and performance status measures. A item index was produced from symptoms that were rated as most important by patients or clinicians. Preliminary evidence suggests that the total score and DRS and FWB subscales are reliable and valid as summary indexes. The TSE subscale may be least relevant given the advent of newer therapies. Depressive symptoms mediate the association between fear of crime and higher body mass index. To investigate pathways in the association between fear of crime and obesity.

A cross-sectional survey was administered among residents aged 18 years and older across all Census tracts. Genesee County, Michigan. A total of residents. Body mass index BMI was calculated by using the respondents' reported height and weight. Composite fear-of-crime and depressive symptoms scores were calculated by using several survey items. Path analysis examined the effects of fear of crime on BMI.

Fear of crime was associated with higher BMI. Depressive symptoms mediated the relationship between fear of crime and BMI p symptoms and BMI p symptoms , which in turn were associated with reduced exercise and subsequently higher BMI. Correlation between vocal tract symptoms and modern singing handicap index in church gospel singers. To verify the correlation between vocal tract discomfort symptoms and perceived voice handicaps in gospel singers, analyzing possible differences according to gender.

All participants answered two questionnaires: Vocal Tract Discomfort VTD scale and the Modern Singing Handicap Index MSHI that investigates the vocal handicap perceived by singers, linking the results of both instruments p symptoms , the higher the vocal handicap for singing. Female gospel singers present higher frequency and intensity of vocal tract discomfort symptoms , as well as higher voice handicap for singing than male gospel singers. The higher the frequency and intensity of the laryngeal symptoms , the higher the vocal handicap will be.

Fluorescein angiography of the bladder: technique and relevance to bladder cancer and interstitial cystitis patients. Fluorescein angiography has been used in the study of bleeding vessels, neovascularity, tumors and ischemic tissues in a variety of disorders.

This pilot study was designed to evaluate the feasibility, safety and relevance of this interesting technology for the evaluation of bladder wall vessels in patients with interstitial cystitis and bladder cancer. Five patients with National Institutes of Health defined interstitial cystitis symptoms and 10 with bladder cancer were studied during cytoscopy while they were under general anesthesia.

A yellow-green barrier filter nm. Patients received a 5 ml. After hydrodistension, glomerulations in interstitial cystitis patients were more prominent with fluorescein angiography and occurred in the venule phase. Areas of papillary transitional cell tumor and carcinoma in situ developed a brilliant yellow-green fluorescence.

Adjacent normal urothelium was nonfluorescent and provided a contrasting dark background facilitating the detection of all lesions. No allergic reaction or other adverse effect related to the fluorescein injection was observed. These unique observations in a limited number of patients suggest that fluorescein angiography of the bladder is a safe and simple procedure. This preliminary report underscores the relevance of fluorescein angiography in the detection of bladder tumor and offers a new approach to the evaluation of bladder wall vessels in interstitial cystitis patients.

Anxiety Sensitivity Index ASI-3 subscales predict unique variance in anxiety and depressive symptoms. Anxiety sensitivity AS has been implicated in the development and maintenance of a range of mental health problems. The development of the Anxiety Sensitivity Index - 3, a psychometrically sound index of AS, has provided the opportunity to better understand how the lower-order factors of AS - physical, psychological, and social concerns - are associated with unique forms of psychopathology.

The present study investigated these associations among 85 treatment-seeking adults with high AS. Participants completed measures of AS, anxiety, and depression. Multiple regression analyses controlling for other emotional disorder symptoms revealed unique associations between AS subscales and certain types of psychopathology. Only physical concerns predicted unique variance in panic, only cognitive concerns predicted unique variance in depressive symptoms , and social anxiety was predicted by only social concerns.

Findings emphasize the importance of considering the multidimensional nature of AS in understanding its role in anxiety and depression and their treatment. Associations between depressive symptoms , self-efficacy, eating styles, exercise and body mass index in women. This article explores cross-sectional associations between depressive symptoms and body mass index BMI in women working in schools in the Greater New Orleans area.

Self-efficacy for eating and exercise, eating styles, and exercise are examined as potential pathways. This is a secondary data analysis of women who were participating in a workplace wellness randomized controlled trial to address environmental factors influencing eating and exercise behaviors using baseline data prior to the intervention. BMI was the primary outcome examined. Path analysis suggested that increased depressive symptoms were associated with increased BMI in women.

Indirect effects of depressive symptoms on BMI were found for increased healthy eating self-efficacy, increased emotional eating, and decreased exercise self-efficacy. The association between greater healthy eating self efficacy and BMI was unexpected, and may indicate a suppressor effect of eating self-efficacy in the relationship between depressive symptoms and BMI in women. The findings suggest the importance of depressive symptoms to BMI in women.

Targets for interventions to reduce BMI include targeting depressive symptoms and related sequelae including self-efficacy for exercise, and emotional eating. Further investigation of eating self-efficacy and BMI are recommended with particular attention to both efficacy for health eating and avoidance of unhealthy foods. Forty-two patients with more than 2 episodes of cystitis in the proceeding 6 months were treated for 3 months with one capsule daily of ECE and observed for a further 6 months.

The primary efficacy criterion was the number of episodes of recurrent cystitis during the 6 months after treatment compared to those during the 6 months before treatment. At the end of the 9-month trial, 34 patients all women were eligible for statistical analysis. Their mean age was The number of recurrences was significantly lower during the 6-month follow-up period than during the 6 months preceding the trial 0. There were no serious adverse events related to the study drug.

Our study demonstrates the efficacy and safety of ECE in the prophylactic treatment of chronically recurrent cystitis. Distribution of mast cell subtypes in interstitial cystitis : implications for novel diagnostic and therapeutic strategies?

To identify the presence and geographical distribution of mast cell MC subtypes: MC T tryptase positive-chymase negative and MC TC tryptase positive-chymase positive in bladder tissue. Stained sections were photographed, and positively stained MCs were quantified using ImageJ. Data were analysed using descriptive statistics and individual paired t-tests. There was a significant difference in the density of MCs between each layer of the disease bladder, with the greatest accumulation within the detrusor p cystitis.

Our results suggest that mastocytosis is present within all layers of disease bladder, especially the muscle layer. A high influx of MC TC in the mucosa of individuals who also had ulceration noted within their diagnostic notes may be of the Hunner's ulcer subclassification.

No commercial use is permitted unless otherwise expressly granted. Clemens, J. Quentin; Clauw, Daniel J. However, no studies have directly compared the characteristics of these syndromes in men and women. However, a substantial proportion of men also report these types of bladder symptoms. A total of 17 studies enrolling patients were identified. Pooled analyses demonstrated that SNM was associated with great reduction in pelvic pain weighted mean difference [WMD] The management of interstitial cystitis IC is predominantly the reduction of the symptoms of frequency, urgency, and pain.

Multimodal treatment approaches for IC are helpful in customizing therapy for individual patients. Complementary and alternative therapies are a quintessential addition to the therapeutic armamentarium and frequently include dietary modification, nutraceuticals, bladder training, neuromodulation, stress reduction, and sex therapy.

Dietary modification involves elimination of bladder irritants, fluid regulation, and a bowel regimen. Nutraceuticals studied for the treatment of IC include calcium glycerophosphate, L-arginine, mucopolysaccharides, bioflavinoids, and Chinese herbs. Bladder training is effective after pain reduction.

The neuromodulation of high-tone pelvic-floor muscle dysfunction is achieved with physical therapy and acupuncture. Stress reduction and sex therapy are best administered by a qualified stress manager and sex therapist. Multimodal, nonconventional management may add efficacy to the treatment of IC. Performance of the American Urological Association Symptom Index with and without an additional urge incontinence item.

We correlated the items and scales and examined whether adding the UI question resulted in better prediction of disease-specific health status. Eighteen women with advanced ovarian cancer completed the NFOSI and participated in cognitive interviews to assess: a the understandability of the NFOSI; and b the things patients have in mind when responding to the item, "I am bothered by side effects of treatment;" and c the interpretation patients place on items relating to fatigue and lack of energy.

Interviews were recorded and transcribed for qualitative analysis. When responding to the item, "I am bothered by side effects of treatment," fatigue, nausea, and neuropathy constituted the most frequently mentioned concerns.

Among the participants who were asked, eight participants responded that "fatigue" and "lack of energy" were the same concept and nine responded they were different. Participants associated "fatigue" with tiredness and associated "lack of energy" with the inability to perform daily tasks and activities. Item revisions, deletions or additions do not appear warranted. Recurrent uncomplicated cystitis in women: allowing patients to self-initiate antibiotic therapy.

Acute uncomplicated cystitis is a lower urinary tract infection occurring in the absence of anatomic or functional abnormalities of the urinary tract or any other complicating factors. The organism responsible is often an enterobacterium, especially Escherichia coli. What is the role of antibiotic therapy for non-pregnant women with recurrent acute uncomplicated cystitis? We reviewed the available evidence using the standard Prescrire methodology.

A single oral dose of fosfomycin trometamol is the antibiotic of choice for treating an episode of acute uncomplicated cystitis. Alternative antibiotics are certain fluoroquinolones or co-trimoxazole a fixed-dose combination of sulfamethoxazole and trimethoprim.

For recurrent acute uncomplicated cystitis , cranberry juice has modest efficacy in reducing the frequency of episodes. A number of non-drug measures are typically proposed, although their effects are unproven: drinking sufficient fluids and urinating regularly; urinating after sexual intercourse; and avoiding spermicides. The strategy that results in the lowest antibiotic exposure is a short course of antibiotics for each episode of urinary tract infection, initiated as soon as clinical symptoms appear.

Long-term antibiotic therapy is sometimes offered. According to one systematic review, women taking long-term prophylactic antibiotic therapy had about 6 times fewer clinical recurrences than with placebo. According to one randomised trial, 3 g of fosfomycin trometamol taken as a single dose every ten days reduced the frequency of recurrence, resulting in 0. When cystitis appears to be associated with sexual intercourse, two small randomised trials suggest that routine postcoital antibiotic treatment is more effective.

Gastroesophageal reflux may contribute to the development of cricopharyngeal dysfunction and Zenker's diverticulum. Common dictum suggests that if upper esophageal sphincter tone is reduced through cricopharyngeal myotomy, symptoms of laryngopharyngeal reflux may worsen. We hypothesized that patients who undergo myotomy should show decreased dysphagia symptoms with concurrent worsening of reflux symptomatology and that these changes would be greater in those patients undergoing complete versus partial myotomy.

A retrospective chart review was performed for patients who underwent endoscopic or open cricopharyngeal myotomy, with or without Zenker's diverticulectomy. Patients who underwent partial myotomy via endoscopic stapling of Zenker's diverticulum were compared with patients who underwent complete myotomy either endoscopic laser-assisted or via an open transcervical approach. The patients were further subdivided into three groups for data analysis: endoscopic staple diverticulotomy, laser cricopharyngeal myotomy, and open approach.

A total of 41 patient charts were reviewed. Of these 41 patients, 17 underwent endoscopic stapler-assisted diverticulotomy, 4 underwent endosopic laser-assisted cricopharyngeal myotomy, and 20 underwent open transcervical cricopharyngeal myotomy, with diverticulectomy as indicated. Mean pre- and postoperative RSIs were Concern for worsening of reflux symptoms following surgery does not appear to be clinically common. Published by. Background Overweight and obese individuals are at increased risk for gastroesophageal reflux disease GERD.

We observed a dose-dependent relationship between increasing BMI and frequent reflux symptoms multivariate P for trend symptoms OR 2. Our findings suggest that even modest weight gain among normal weight individuals may cause or exacerbate reflux symptoms. This study examined the association between body mass index BMI changes over time and the risk of elevated depressive symptoms in a cohort of Midwestern rural adults.

The longitudinal study used data from a telephone survey in including 1, men and women enrolled in the Walk the Ozarks to Wellness Project from 12 rural communities in Missouri, Arkansas, and Tennessee. For each unit increase in BMI over time, representing an average increase of about 5. Our findings hold important public health implications given the increasing rates of overweight and obesity over the past couple of decades, particularly among rural adults.

BK virus-associated hemorrhagic cystitis in a pediatric lung transplant recipient. BKV was first postulated to be a potential pathogen in when it was isolated in the urine of a renal transplant recipient. The pathology of BKV is generally confined to the urinary tract. In renal transplant recipients, BKV has been associated with hemorrhagic cystitis , urethral stenosis, and interstitial nephritis. Reports of BKV infection in lung transplant recipients are limited to a few case reports in adult patients.

To our knowledge, there are no published reports of pediatric lung transplant recipients with BKV-associated hematuria. We hereby report a case of BKV-induced hemorrhagic cystitis in a pediatric lung transplant recipient. Koufman proposed the term to designate Laryngeal Pharyngeal Reflux LPR symptoms , signs or tissue damage resulting from aggression of the gastrointestinal contents in the upper aerodigestive tract.

Belafsky et al proposed a score that points to inflammatory laryngeal signs through videolaryngoscopic findings, the Reflux Finding Score RFS. The objective of this study is to provide a comparison between the Reflux Finding Score and the Reflux Symptom Index in the practice of Otorhinolaryngology.

We excluded nine patients and the study group was patients. The study group consisted of patients 88 women and 38 men. Their main complaints were cough The RSI ranges from 13 to 42 with a mean of The RFS ranged from 3 to 19 with a mean of 9.

Based on the clinical index , the specialist can evaluate the need for further tests. Ultrasonography in the diagnosis of hemorrhagic cystitis — a complication of bone marrow transplantation in pediatric oncology patients. Objective The aim of this study was to evaluate the usefulness of ultrasonography in the diagnosis of hemorrhagic cystitis following bone marrow transplantation in children.

Material and methods The study involved an analysis of clinical material and the results of imaging tests performed in patients who underwent hematopoietic cell transplantation. Ultrasonographic findings in 42 patients with hemorrhagic cystitis were analyzed in detail. The ultrasound images served to assess the severity of hemorrhagic cystitis and the results were compared with the clinical assessment of the disease on the Droller scale, as well as the laboratory and endoscopic tests.

Results In the studied group of patients hemorrhagic cystitis following allogeneic transplantation was diagnosed in The study revealed a higher incidence of hemorrhagic cystitis in children above 10 years of age. Grade 3 according to the Droller was diagnosed in The number of ultrasound examinations depended on the clinical symptoms , severity, duration and co-occurrence of other complications following the transplantation and was within the 1—15 range average: 4.

Grades 3 and 4 were related to the poor clinical condition of the patients and to their longer hospitalization. During this period there was an increased risk of renal malfunction and acute renal failure, post-inflammatory narrowing of the ureters, hydronephrosis, and in grade 4 the fibrosis of the bladder with reduced bladder capacity. Analyses demonstrated a significant correlation between the ultrasound image of the bladder wall and the clinical severity. Conclusions Ultrasound with Doppler options remains the primary diagnostic tool in the evaluation of hemorrhagic cystitis , and is useful in terms of its diagnosis, determination of the severity, and.

The objective of the present study was to evaluate the effectiveness of N-acetylcysteine, D-mannose and Morinda citrifolia fruit extract NDM , when associated to antibiotic therapy, in reducing the persistence of recurrent cystitis in this risk population.

Patients and Methods: Sixty breast cancer survived women with recurrent cystitis were retrospectively examined. Group 1, comprised of 40 patients treated with antibiotic therapy associated with NDM lasting for six months, Group 2 comprised of 20 patients treated with antibiotics alone. Results: The use of NDM in combination with antibiotic therapy showed a significant reduction in positive urine cultures, compared to antibiotics alone.

Subjects of Group 1 rather than those of Group 2, showed improvement in symptoms score of urgency, frequency, urge incontinence, recurrent cystitis , bladder and urethral pain. Conclusion: In breast cancer survived women affected by genitourinary discomfort, the combination of NDM and antibiotic therapy showed a greater efficacy in reducing urinary tract infections and urinary discomfort with respect to antibiotic use only.

Breast cancer survivors in adjuvant therapy, frequently experience the estrogen deficiency with genitourinary symptoms mostly represented by recurrent bacterial cystitis. Sixty breast cancer survived women with recurrent cystitis were retrospectively examined. The use of NDM in combination with antibiotic therapy showed a significant reduction in positive urine cultures, compared to antibiotics alone.

In breast cancer survived women affected by genitourinary discomfort, the combination of NDM and antibiotic therapy showed a greater efficacy in reducing urinary tract infections and urinary discomfort with respect to antibiotic use only. George J. Delinasios , All rights reserved. The bladder pain syndrome BPS is a spectrum of urological symptoms characterised by bladder pain with typical cystoscopic features.

Diagnosis and management of this syndrome may be difficult. There is no evidence-based management approach for the diagnosis or treatment of BPS. The objective of this study was to critically review and summarise the evidence relating to the diagnosis and treatment of the bladder pain syndrome.

A review of published data on the diagnosis and treatment of the BPS was performed. Our search was limited to English-language articles, on the "diagnosis", and "management" or "treatment" of "interstitial cystitis " and the "bladder pain syndrome" in "humans. All urodynamic volumes are reduced in patients with BPS. Associated conditions include psychological distress, depression, history of sexual assault, irritable bowel syndrome and fibromyalgia.

Cystoscopy remains the test for definitive diagnosis, with visualisation of haemorrhage on cystoreduction. A multidisciplinary treatment approach is essential in the management of this condition. Orally administered amitriptyline is an efficacious medical treatment for BPS. Sacral or pudendal neuromodulation is effective, minimally invasive and safe. Surgery is reserved for refractory cases.

There remains a paucity of evidence for the diagnosis and treatment of BPS. We encountered significant heterogeneity in the assessment of symptoms , duration of treatment and follow up of patients in our literature review. Chart reviews and telephone surveys were then conducted to determine their posttherapy course.

Of 68 eligible women, 55 Their mean age at therapy onset was At the end of the follow-up period, 19 of the 55 women Univariate and multivariate analyses showed that DMSO treatment failure was more likely in patients with pretreatment day-time urinary frequency more than 15 episodes per day OR 1.

Prevention of Cystitis : Travelling between the Imaginary and Reality. As a preventive strategy, increased water intake is often recommended to women affected by recurrent cystitis ; however, clinical data are sparse and conflicting. This review evaluates the preventive approaches used as alternatives to obtain relief from the burden of cystitis and focuses on the effect of fluid intake on urinary tract infection.

Karger AG, Basel. Risk factors for recurrent cystitis following acute cystitis in female patients. We conducted a retrospective analysis of acute cystitis AC patients to evaluate the risk factors of recurrent cystitis RC patients following AC. The clinical records of subjects with a confirmed diagnosis of AC and 90 healthy subjects who visited the Health Promotion Center between and were reviewed.

Jarrett Allen had 18 points and 10 rebounds for the Cavaliers. Seven Raptors hit at least one 3-pointer, with Kyle Lowry leading the way with 5-for-9 shooting from deep. He finished with 21 points. Russell Westbrook had 23 points, seven assists and six rebounds. Terry Rozier led the Hornets with 34 points, connecting on 12 of 17 shots. Bridges had 10 rebounds. The Associated Press. Trae Young was furious. But did he flop? The league's initial reaction to Cuban's decision was to say teams were free to conduct pregame activities as they wished with the unusual circumstances created by the coronavirus pandemic.

Most teams don't have fans at home games. But the NBA abruptly reversed course with Cuban's decision reverberating around the country, including a question put to White House press secretary Jen Psaki during her daily briefing. The Mavericks played a prerecorded anthem with both teams standing along the free throw lines, as spelled out in NBA guidelines, before Wednesday night's win over Atlanta.

In the past, Cuban always had live performances of the anthem, although that practice has changed across all sports because of the pandemic. Less than half of the roughly 1, vaccinated essential workers were at their seats during the anthem. All players and coaches stood, including Dallas coach Rick Carlisle with his right hand over his heart.

He was steadfast about it. It's been quite a day. We feel that their voices need to be respected and heard, because they have not been. Rich Patterson, a year-old who works in health care and attended the Atlanta game with a colleague, said the anthem was important to him, but that he wasn't hung up on whether it was played before sporting events. The move wasn't without support among NBA coaches. What good reason is there to play the anthem before a game? The NBA rule book does not specifically say that the anthem — or anthems, in games involving the Toronto Raptors, the lone Canadian team in the league — must be played before games.

The outspoken billionaire said the issue was part of an ongoing conversation with people in the community and the league, particularly as fans begin returning to arenas. My hand is always over my heart. Patrick said he intends to introduce a bill in the Texas Senate that will ensure the national anthem is played at all events that receive public funding. He said the bill has broad support. Naz Reid led Minnesota with 23 points off the bench, and Malik Beasley added The Timberwolves have lost three in a row and eight of Minnesota led by as many as 13 points in the first half before watching its lead disappear.

The Timberwolves' bench built up the first-half lead behind strong efforts from Jaylen Nowell and rookie Jaden McDaniels. Trailing by six at the half, the Clippers used an run to take the lead early in the third quarter. Patrick Beverley returned for the Clippers following an eight-game absence with a right knee injury.

Towns and Russell have played just five games together since Minnesota acquired Russell in a trade on Feb. Russell remains day-to-day. George is second on the Clippers in scoring this year, averaging Timberwolves: McDaniels had four blocks in the first half, a career high.

Timberwolves: Minnesota heads on the road to take on Charlotte on Friday. Anderson opened the second half with four 3-pointers in less than 3 minutes, leading to a Charlotte timeout. Later in the quarter, the Grizzlies had a run and the Memphis lead swelled to at the end of the third. Memphis outscored the Hornets in the frame as Charlotte, which shot well in the first half, converted only six of its 20 shots.

Charlotte never threatened the rest of the way. Both teams started the game shooting well, but Memphis was hindered by a handful of turnovers and a half dozen fouls in the first quarter. The Hornets were still shooting Still, Memphis shot well enough for a lead at the break. Rozier had 24 for Charlotte, while Allen led Memphis with 16 points. Grizzlies: Have won four straight against Hornets. Tennessee Republicans advanced a bill requiring student-athletes to participate in sports based on the sex of their birth certificates.

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