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Afirmava que viviam em perfeito acordo sobre todos os assuntos que consideravam. Pertencemos um ao outro. Entre mil sorrisos, o seu. Destro ou canhoto? Casas e riquezas herdam-se dos pais, mas a esposa prudente vem do Senhor. Consulte a Deus quando tiveres de escolher uma companheira o para a vida. Antes de casar-se, somente de si mesmo, parece, deveria preocupar-se; entretanto casado assume sobre seus ombros novas responsabilidades. Sem o amor, como se decidiria uma mulher a consagrar sua vida inteira a um homem?
Se amar vossa mulher e quereis a vossa ventura, guarde a fidelidade para com ela. Hebreus Compartilhar. Tornam-se ainda mais legitimados os sistemas alternativos uma vez que o tradicional formato concentrado no modelo estado-juiz encontra-se saturado. Isto porque, essa dicotomia direito estatal versus alternativo se mostrou ultrapassada. Curso Para Mediadores. A Era dos Direitos.
Rio de Janeiro: Elsevier, , p. Porto Alegre: Fabris, , p. Projeto Comunidade do Jacarezinho. O discurso e o poder. Palavras-chave: Teoria dos Direitos Humanos. ABSTRACT: The subject of discussion in this work is focused on the ontological or ethical foundation of human rights, either in its universalist proposal, either in relativistic proposal, either as prescription or description of reality, or, still immersed in the political context of violence, the means and the purpose to be desired.
Thus, it seeks to make a theoretical analysis, bibliographic nature, based on the following initial question: Is it possible to talk about just a theory of human rights? Our premise is that, although justified as divine, transcendental, rational or natural, human rights have historicity, contingency, political and economic, serving at the same time as a focus of resistance to oppression and as the source of that oppression in a scenario International.
We will analyze the reasons of human rights in the three proposals already listed at the beginning of the abstract. Our conclusion that human rights are contingent, historical, domination, rhetoricians, class and violence and oppression justification speech.
Still, the ideas that abalizou 1. UFPB E-mail: moises. Keywords: Human Rights Theory. Critical Theory. Ethics of Means and Purposes. Dito de outra forma, restringindo o escopo da pergunta: Em que momento dessa Assembleia Francesa as demais etnias tiveram direito a voz e voto?
Marx analisa, ambiguamente, os direitos humanos. A ele remetemos o leitor, para leitura complementar. Assim diz Hume :. Mas porque esse Direito deve ser superado? Palavras-chave: Benjamin Cardozo. Ventajas : Perfecto para estancias cortas en agencia matrimonial barcelona opiniones que necesitas aeropuerto cerca. Legitimization in world society. Ventajas: Close to the boa Viagem beach with great facilities and amenities. Will definitely never come back to this place! In the present study, the authors describe clinical and medico-legal aspects involved in violent behavior investigation.
Cosm agencia matrimonial opiniones - How to get a good woman. Acesso em: 26 out. Acesso em: 25 out. Origens do totalitarismo: antissemitismo, imperialismo e totalitarismo. Marx y los derechos humanos. Desenho quer namorar comigo Contents: Como a literatura infantil pode ajudar? Pauci-immune necrotizing glomerulonephritis is the most frequent cause of rapidly progressive glomerulonephritis and, in most cases, is associated with antineutrophil cytoplasmic antibodies ANCA.
It is either the renal manifestation of Wegener's granulomatosis, microscopic polyangiitis of. Bartonella Endocarditis and Pauci-Immune Glomerulonephritis. Raybould, Jillian E. Abstract Among culture-negative endocarditis in the United States, Bartonella species are the most common cause, with Bartonella henselae and Bartonella quintana comprising the majority of cases. Kidney manifestations, particularly glomerulonephritis, are common sequelae of infectious endocarditis, with nearly half of all Bartonella patients demonstrating renal involvement.
Although a pauci-immune pattern is a frequent finding in infectious endocarditis—associated glomerulonephritis, it is rarely reported in Bartonella endocarditis. Anti—neutrophil cytoplasmic antibody ANCA positivity can be seen with many pathogens causing endocarditis and has been previously reported with Bartonella species. In addition, ANCA-associated vasculitis can also present with renal and cardiac involvement, including noninfectious valvular vegetations and pauci-immune glomerulonephritis.
Given the overlap in their clinical presentation, it is difficult to differentiate between Bartonella endocarditis and ANCA-associated vasculitis but imperative to do so to guide management decisions. We present a case of ANCA-positive Bartonella endocarditis with associated pauci-immune glomerulonephritis that was successfully treated with medical management alone. Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis. Finally, we show that infections with fimbriated pathogens are common before the onset of FNGN.
Antineutrophil cytoplasmic antibody—negative pauci-immune glomerulonephritis with massive intestinal bleeding. Full Text Available A year-old woman was admitted to hospital because of generalized edema and proteinuria. Her renal function deteriorated rapidly. Serum immunoglobulin and complement levels were within normal ranges.
An autoantibody examination showed negative for antinuclear antibody and antineutrophil cytoplasmic antibody. Histologic examination of a renal biopsy specimen revealed that all of the glomeruli had severe crescent formations with no immune deposits. The patient was treated with steroid pulse therapy with cyclophosphamide followed by oral prednisolone. Fifteen days later, she experienced massive recurrent hematochezia. Angiography revealed an active contrast extravasation in a branch of the distal ileal artery.
We selectively embolized with a permanent embolic agent. On the 45th hospital day, the patient suddenly lost consciousness. Brain computed tomography showed intracerebral hemorrhage. We report a case of antineutrophil cytoplasmic antibody—negative pauci-immune glomerulonephritis with massive intestinal bleeding and cerebral hemorrhage.
Full Text Available A rare and a disease of unknown etiology, Churg-Strauss syndrome CSS is a granulomatous necrotizing small vessel vasculitis characterized by the presence of asthma, sinusitis, and hypereosinophilia, which is initially described by Churg and Strauss in The ANCA status may dictate the clinical phenotype. The objective of this case report is to point out the possibility of vasculitic rash in ANCA-negative CSS in a year-old man and the disease rarely occurs in Bangladeshi population.
We analyze the history, clinical examinations and relevant investigations related to the patient to establish the diagnosis in our department. The clinical scenario and biopsy help us to attain the diagnosis. But due to unavailability of patients' cohort we have limitations of comparison of ANCA status in Bangladeshi populations.
Additional immunosuppressive agents like cyclophosphamide, mycophenolate mofetil, azathioprine, rituxin1ab are occasionally added in patients with more advanced or refractory disease. Levamisole has been increasingly used as an adulterant of cocaine in recent years, emerging as a public health challenge worldwide. Levamisole-associated toxicity manifests clinically as a systemic vasculitis, consisting of cutaneous, hematological, and renal lesions, among others.
Purpura retiform, cutaneous necrosis, intravascular thrombosis, neutropenia, and less commonly crescentic nephritis have been described in association with anti-neutrophil cytoplasmic antibodies ANCAs and other autoantibodies. Here we report the case of a year-old male who was a chronic cocaine user, and who presented spontaneous weight loss, arthralgia, and 3 weeks before admission purpuric skin lesions in the earlobes and in the anterior thighs.
His laboratory tests on admission showed serum creatinine of 4. Urine toxicology screen was positive for cocaine and levamisole, with Skin and renal biopsies were diagnostic for leukocytoclastic vasculitis and pauci-immune crescentic glomerulonephritis, respectively.
The patient showed a good clinical response to cocaine abstinence, and use of corticosteroids and intravenous cyclophosphamide. Last serum creatinine was 1. In levamisole-induced systemic vasculitis, the early institution of cocaine abstinence, concomitant with the use of immunosuppressive drugs in severe cases, may prevent permanent end organ damage and associate with better clinical outcomes.
Full Text Available Levamisole has been increasingly used as an adulterant of cocaine in recent years, emerging as a public health challenge worldwide. Hydralazine-induced pauci-immune glomerulonephritis: intriguing case series with misleading diagnoses. Full Text Available Hydralazine has been used since the s for the management of hypertension.
Evidence for hydralazine-associated vasculitis dates to pre-ANCA antineutrophil cytoplasmic antibodies era. This abstract describes two cases of ANCA-positive pauci-immune glomerulonephritis GN in challenging scenarios where diagnosis was misconstrued. A comprehensive literature review was done to understand the pathogenesis of drug-induced pauci-immune GN.
We have described key diagnostic features that are helpful in distinguishing idiopathic ANCA vasculitis from drug-induced vasculitis. Additionally, we have also described different treatments meant to provide therapy options with the least side effects. Both the innate and the acquired immune system are involved in the pathophysiology of renal vasculitis.
However, anti-neutrophil cytoplasmic antibody ANCA -associated renal vasculitis is characterized by a ' pauci-immune ' pattern of immunofluorescence during kidney biopsy, indicating the relative. Full Text Available A year-old man presented with epistaxis, nasal obstruction and a subcutaneous swelling over the left malar region with radiological evidence of a mass in the right nasal cavity.
Histology of the lesions showed necrotizing granuloma with evidence of vasculitis. There was no other systemic involvement and the patient was ANCA-negative. Excellent response to systemic steroid and cyclophosphamide therapy was noted.
Patterns of glomerulonephritis with crescents : Experience at a tertiary medical center in Saudi Arabia. Full Text Available A series of 78 cases of glomerulonephritis GN, in which renal biopsy revealed changes of GN associated with crescent formation, were reviewed. In most of the cases This was followed by pauci-immune GN The percentage of glomeruli with crescents was the highest in cases of anti-GBM disease mean of These changes were generally more pronounced in a subset of pauci-immune GN associated with serum elevation of antineutrophil cytoplasmic antibody c-ANCA.
In biopsies from patient with immune complex disease, systemic lupus erythematosus was the most common cause of crescentic GN. ANCA-associated pauci-immune glomerulonephritis in a patient with bacterial endocarditis: a challenging clinical dilemma.
Purpose: We report the case of a year-old man with chronic hepatitis B and C infection presenting with acute kidney injury and enterococcus faecalis-infective endocarditis IE. Methods: On systematic review of the literature, we found five previous cases We report the case of a year-old man with chronic hepatitis B and C infection presenting with acute kidney injury and enterococcus faecalis-infective endocarditis IE. On systematic review of the literature, we found five previous cases whereby IE caused by streptococcus and bartonella species were related to ANCA vasculitis-associated GN.
Most reports of IE-related GN are mediated by immune complex deposition and resolve following microbial clearance. A paucity of reports on the development of GN in IE-associated ANCA vasculitis exists, highlighting the rarity of our case and lack of clear therapeutic strategies in a patient with active infection requiring immunosuppression. In this case, the patient's chronic hepatitis B and C coinfection presented a unique challenge. Eosinophilic granulomatosis with polyangiitis EGPA, previously named Churg-Strauss syndrome is a form of necrotizing vasculitis occurring in patients with asthma and eosinophilia.
Ischemic stroke is a relatively rare complication of the disease. Elevated cardiac enzymes and cardiac magnetic resonance imaging were consistent with endomyocarditis. The simultaneous presence of history of asthma, sinusitis, hypereosinophilia, and vasculitis led to the diagnosis of EGPA. This case contributes to the recent debate of the 2 possible presentations of the disease according to the ANCA antineutrophil cytoplasmic antibodies status.
We furthermore underscore the need for careful differential diagnosis of the " ANCA negative " cases with persistent hypereosinophilia from the idiopathic hypereosinophilic syndrome. Published by Elsevier Inc. All rights reserved. Crescentic glomerulonephritis: A clinical and histomorphological analysis of 46 cases. Objectives: The present study was aimed at evaluating the various clinical, biochemical and histological parameters in CrGN with respect to these categories and clinical outcome.
Clinical and laboratory parameters were retrieved along with the therapeutic approach and clinical outcome, wherever available. Renal biopsy slides were evaluated for various glomerular, tubulo-interstitial and arteriolar features. Appropriate statistical tests were applied for significance. Results: A total of 46 cases of CrGN were included; majority Four unusual associations, including idiopathic membranoproliferative glomerulonephritis MPGN, multibacillary leprosy, acute lymphoblastic leukemia and C1q nephropathy were detected.
Of these, 11 Conclusions: Crescentic glomerulonephritis remains one of the main causes of acute renal failure with histological diagnosis. Immunohistologic examination is essential for accurate classification into one of the three categories. This condition should be considered. Crescentic glomerulonephritis in non-asthmatic Churg-Strauss syndrome.
Full Text Available A year-old male presented with sensory motor polyneuropathy and rapidly progressive renal failure. Investigations revealed marked peripheral eosinophilia and elevated perinuclear antineutrophil cytoplasmic antibody titers. Renal biopsy showed pauci-immune cre-scentic glomerulonephritis with interstitial eosinophil infiltrates. He had no history of asthma. Computed tomography of the chest and X-ray of the paranasal sinuses were normal. On Day 1, the patient developed ileal perforation.
Resected ileal segments showed small vessel vasculitis with extravascular eosinophils. A diagnosis of non-asthmatic variant of Churg-Strauss syndrome was made. Renal recovery was achieved in 12 weeks with a combination therapy of corticosteroid and cyclophosphamide. The patient has been relapse-free for 12 months on oral prednisolone therapy. A year-old male presented with sensory motor polyneuropathy and rapidly progressive renal failure.
Clinical presentation of Churg-Strauss syndrome in children. Razenberg Femke ; J. Heynens Jan ; G. Jan de Vries Geeuwke ; L. Duijts Liesbeth ; J. Rosias Philippe. We report on a year-old boy with asthma and deterioration of his general condition, who was eventually diagnosed with an ANCA-negative Churg-Strauss syndrome.
Anti-neutrophil cytoplasmic antibody negative crescentic paucimmune glomerulonephritis in a case of scleroderma with systemic lupus erythematosus overlap. Full Text Available Renal Involvement in scleroderma is a known problem and the manifestations are well described. Renal involvement in systemic lupus erythematosus SLE is also well known. However, in scleroderma and SLE overlap syndrome, the renal findings may vary being a combination of features of immune complex mediated glomerulonephritis as well as thrombotic microangiopathy.
We report a case in which the renal manifestation in such a situation was of a focal necrotising pauci-immune glomerulonephritis with crescents , anti-neutrophil cytoplasmic antibody negative. To the best of our knowledge, such manifestations have not been described before. Renal dysfunction in a normotensive setting in such a case should direct one towards evaluation for other causes and should prompt a kidney biopsy. This would be valuable in delineating the pathological process in the kidney and would help in guiding therapy.
Churg-Strauss syndrome is an uncommon multisystem disorder characterized by asthma, eosinophilia and vasculitis. The propositus included, 50 cases of childhood Churg-Strauss syndrome have been reported. The patient characteristics and clinical characteristics of these children are summarized. The respiratory tract is most frequently involved with pulmonary infiltrates, asthma and sinusitis.
Early recognition of childhood Churg-Strauss syndrome is important as delayed diagnosis can lead to severe organ involvement, and possible fatal outcome. Isolated pauci-immune pulmonary capillaritis. Full Text Available A young house wife presented with low grade fever, cough, haemoptysis and SOB of unknown aetiology for 40 days duration. Respiratory system examination revealed diffuse crepts and rhonchi.
Other organ system examination did not reveal any abnormality. X-ray chest PA view and CT thorax showed diffuse bilateral necrotising nodular lesions of various sizes with small pleural effusion. She also had low resting oxygen saturation with falling haematocrit.
Bronchoscopy revealed continuous bloody aspirates. We could not isolate any organisms in any of the specimens from her and she was unresponsive to any of the antibiotics either. Based on the clinical, laboratory data, radiological features and positive outcome to pulse therapy of methylprednisolone and cyclophosphamide, she was diagnosed as a case of IPIPC.
Clinical spectrum and outcomes of crescentic glomerulonephritis: A single center experience. Full Text Available There is limited data on the etiology, clinical and histopathological spectrum and outcomes of crescentic glomerulonephritis CrGN in adult Indian population. This prospective study was done to evaluate the etiology, clinicohistological patterns and predictors of outcome of CrGN in South Indian population.
All the patients received standard protocol based immunosuppression in addition to supportive care. The patients with PauciGN presented with significantly higher serum creatinine 9. At the end of 3 months follow-up, only two patients went into complete remission 5.
Majority of the patients had end-stage renal failure There was no signifi difference in the renal survival The parameters associated with adverse outcomes at 3 months were hypertension odds ratio [OR]: 0. A year-old female, having developed recurrent infections of the upper airway, hoarseness, dyspnea, and nasal congestion, was referred to our department.
There was no history of trauma or intubation. The subglottic space was circularly narrowed. The test for c-ANCA was negative. Chest X-ray and renal function were normal. A tracheotomy was performed; the histology showed infiltrating plasma cells, but no signs of vasculitis or granulomatous inflammation.
One year later the patient developed acute renal failure. Biopsy of the kidney confirmed Wegener's disease. The laryngeal stenosis completely resolved after therapy with cyclophosphamide. Juvenile Wegener's granulomatosis is extremely rare; the larynx and trachea seem to be involved more frequently in children than in adults. Surgical interventions within the larynx or trachea might only be considered after ineffective therapy with immunosuppressive drugs.
A compact high-beta tokamak configuration with '' crescent ''-shaped or ''boomerang''-shaped cross-section is proposed as a next-generation ignition machine. This configuration with a small indentation but a large triangularity is more compact than the normal dee-shaped design because of its high-beta characteristics in the first-second transition regime of stability.
This may also be a more reliable next-generation compact device than the bean-shaped design with large indentation and small triangularity, because this design dose not rely on the second stability and is easily extendable from the present dee-shaped design. A compact high-beta tokamak configuration with '' crescent ''-shaped or ''boomerang''-shaped cross section is proposed as a next-generation ignition machine.
This may also be a more reliable next-generation compact device than the bean-shaped design with large indentation and small triangularity, because this design does not rely on the second stability and is easily extendable from the present dee-shaped design. Hypocomplementemic urticarial vasculitis syndrome HUVS is a rare autoimmune disease characterized by multiple organ system involvement, including renal disease, with low complement levels.
We report the case of a year-old woman who presented with nonspecific symptoms including fatigue, diarrhea, macular rash and abdominal pain with acute renal failure leading to end-stage kidney disease. Laboratory results showed hematuria, nephrotic range proteinuria, worsening creatinine and low C1q levels.
Left kidney biopsy showed proliferative glomerulonephritis with crescent formation. She was treated with 6 months of intravenous cyclophosphamide, followed by 2 doses of intravenous rituximab 1g each , thereafter maintained on mycophenolate mofetil and glucocorticoid-based therapy. She experienced a full recovery of renal function after 12 months of dialysis dependence. Hypocomplementemic urticarial vasculitis syndrome with crescentic glomerulonephritis is a rare disease with only 5 other reported cases in literature.
In our case, we document a delayed but excellent renal recovery during a 2-year follow-up. We report a rare case of crescentic diffuse proliferative glomerulonephritis GN that developed in close temporal association with cetuximab treatment. A year-old female recently completed chemotherapy with cetuximab treatment for moderately differentiated oral squamous cell carcinoma.
She was admitted with acute renal failure and nephrotic-range proteinuria. Laboratory data showed serum creatinine of 6. Serum C3 and C4 level were normal. Renal biopsy showed crescentic diffuse proliferative GN with focal features of thrombotic microangiopathy.
Patient was started on cyclophosphamide and steroids. Her renal function did not improve on day 8 and she was started on hemodialysis. Previous reports suggest that EGFR-targeting medications can possibly trigger or exacerbate an IgA-mediated glomerular process leading to renal failure.
This case suggests that cetuximab therapy may have triggered or exacerbated a severe glomerular injury with an unfavorable outcome. Treating physicians should maintain a high degree of caution and monitor renal function in patients on EGFR inhibitors. This grid is Crescentic glomerulonephritis in a polar bear Ursus maritimus. Spontaneous crescentic glomerulonephritis CrGN in animals has only been reported in dog and sheep.
We report the pathological features of CrGN in a year-old male polar bear that died due to renal failure. Histologically, the lesions were characterized by fibrocellular crescents , adhesion between Bowman's capsule and the glomerular capillary tuft and an increase in the mesangial matrix in glomeruli.
Ultrastructually, thickening of the glomerular basement membrane and loss of epithelial cell foot processes were observed with electron-dense deposits. Crescentic Glomerulonephritis in a Polar Bear Ursus maritimus. Subtotal ablation of parietal epithelial cells induces crescent formation. Sicking, E. Here, we established. Here, we established an inducible transgenic mouse to allow subtotal ablation of PECs.
Proteinuria developed during doxycycline-induced cellular ablation but fully reversed 26 days after termination of doxycycline administration. Podocytes showed focal foot process effacement, which was the most likely cause for transient proteinuria. The induced proliferation of PECs persisted throughout the observation period, resulting in the formation of typical cellular crescents with periglomerular infiltrate, albeit without accompanying proteinuria.
In summary, subtotal ablation of PECs leads the remaining PECs to react with cellular activation and proliferation, which ultimately forms cellular crescents. Crescent City recorded the highest amplitudes of any tide gauge in the Pacific and was the only location to experience structural damage. Strong currents damaged docks and boats within the small boat basin, causing more than US 20 million in damage and replacement costs.
We examine how modifications to Crescent City's harbor may have affected its vulnerability to moderate tsunamis such as the event. A bathymetric grid of the basin was constructed based on US Army Corps of Engineers soundings in and before the construction of the small boat basin.
The method of splitting tsunamis was used to estimate tsunami water heights and current velocities at several locations in the harbor using both the grid and the bathymetric grid for the Kuril event and a similar-sized source along the Sanriku coast of Japan.
Model velocity outputs are compared for the two different bathymetries at the tide gauge location and at six additional computational sites in the harbor. The largest difference between the two grids is at the small boat basin entrance, where the bathymetry produces currents over three times the strength of the currents produced by the bathymetry. Peak currents from a Sanriku event are comparable to those produced by the event, and within the boat basin may have been higher.
The modifications of the harbor, and in particular the addition of the small boat basin, appear to have contributed to the high current velocities and resulting damage in and help to explain why the M w 8. Crescentic glomerular nephritis associated with rheumatoid arthritis: a case report.
Rheumatoid arthritis is a systemic disorder where clinically significant renal involvement is relatively common. However, crescentic glomerular nephritis is a rarely described entity among the rheumatoid nephropathies. We report a case of a patient with rheumatoid arthritis presenting with antineutrophil cytoplasmic antibody-negative crescentic glomerular nephritis.
Her physical examination revealed that she had bilateral pitting leg edema and periorbital edema. She was not pale or icteric. She had evidence of mild synovitis of the small joints of the hand bilaterally with no deformities. No evidence of systemic vasculitis was seen.
Abdominal ultrasound revealed normal-sized kidneys with acute parenchymal changes and mild ascites. Her renal biopsy showed renal parenchyma containing 20 glomeruli showing diffuse proliferative glomerular nephritis, with 14 of 20 glomeruli showing cellular crescents , and the result of Congo red staining was negative. Antistreptolysin O titer rheumatoid arthritis, awareness of which would facilitate early appropriate investigations and treatment. Beta limit of crescent and bean shaped tokamaks.
The poloidal plasma cross-sections are inscribed in a rectangle with an aspect ratio of three and an ellipticity of two. A confocal wall, the distance of which from the plasma surface is equal to the horizontal minor plasma radius, is present to stabilize against the kink mode.
It is also shown that the coefficient of the Troyon-type beta scaling increases for an indented plasma. For strong indentation, the BEAN 2 type gives the highest beta value. Ocular involvement in Churg-Strauss syndrome is infrequent. We describe the case of a year-old woman with eosinophilia and involvement of the respiratory tract, skin, and peripheral nervous system, fulfilling the American College of Rheumatology criteria for Churg-Strauss syndrome.
The patient presented with acute, painless vision loss in her right eye. Central retinal artery occlusion CRAO without accompanying retinal vasculitis was diagnosed by angiographic findings and funduscopic findings of retinal whitening with a cherry-red spot. Although her antineutrophil cytoplasmic antibody ANCA status was negative, CRAO was thought to be an ocular manifestation of Churg-Strauss syndrome, and appropriate treatment was planned.
She was treated with high-dose corticosteroids and anticoagulant therapy. Her macular edema improved, but visual recovery was poor. Full Text Available The origin of crescent forming cells in human glomerulonephritis GN remains unknown. We investigated the expression of claudin-1 in human GN. Immunohistochemistry for claudin-1 was performed on 17 kidney biopsy samples with crescent formation.
Colocalization of claudin-1 with intracellular tight junction protein ZO-1 was also evaluated by immunofluorescence double staining. Claudin-1 is expressed mainly at the cell to cell contact site of proliferating cells in cellular crescentic lesions in patients with these forms of human GN. Small numbers of crescent forming cells showed extrajunctional localization of claudin Colocalization of claudin-1 with ZO-1 was found at cell to cell contact sites of adjacent proliferating cells.
In control samples, staining of claudin-1 was positive in PECs, but not in podocytes. Our findings suggest that claudin-1 contributes to crescent formation as a component of the tight junction protein complex that includes ZO Recent drying of the Fertile Crescent : natural or externally forced? There has been a reduction in observed precipitation over the greater Mediterranean region since the middle of the 20th Century. Recent studies suggest that while anthropogenic forcing has already begun to assert itself in recent decades, the preponderance of the winter drying trend is attributable to the large natural multidecadal variability of the North Atlantic Oscillation NAO , while over the eastern Mediterranean, the anthropogenic, or forced drying signal is more clearly evident.
This forced drying is projected to increase during the 21st Century according to the newest global climate models and this aridification would present significant challenges for a region that is already water-stressed. Although the Fertile Crescent is historically known for its agricultural prosperity, the severity and persistence of the recent multiyear drought in Syria, directly prior to the uprising there, leads us to ask whether this is evidence of emerging global warming influence.
This drought exacerbated existing water insecurity, resulting in an agricultural collapse and a mass migration of rural drought refugees to the urban areas in Syria's west. This migration followed the previous influx of Iragi refugees and combined with strong natural population growth to place a severe strain on resources.
Here we examine observations of precipitation and temperature, both gridded and stations, along with simulations and projections from the newest global climate models, to estimate the forced contribution to the recent Syrian drought, and assess the uncertainty in future drying according to the models.
We find that this region has experienced a long-term downward trend in precipitation, and a concomitant increase in temperature, serving to further dry the soil, and in surface pressure. We find that the shift in the distributions of three-year running means of surface pressure and precipitation due to the forcing make severe events such as the recent Syrian drought several.
Coexistence of anti-glomerular basement membrane antibodies and myeloperoxidase-ANCAs in crescentic glomerulonephritis. In the present study, we questioned. Renal progenitor cells contribute to hyperplastic lesions of podocytopathies and crescentic glomerulonephritis. Smeets, B. Glomerular injury can involve excessive proliferation of glomerular epithelial cells, resulting in crescent formation and obliteration of Bowman's space.
The origin of these hyperplastic epithelial cells in different glomerular disorders is controversial. Renal progenitors localized to the inner. Full Text Available Introduction: Bioterrorism is a worldwide problem and has been the focus of attention during recent decades.
There is no precise information on the knowledge, attitude, and preparedness of Iranian Red Crescent volunteers in dealing with bioterrorism. Therefore, the present study aimed to evaluate the above-mentioned parameters in Mahabad Red Crescent Society volunteers. Methods: In this prospective cross-sectional study, the knowledge of volunteers was evaluated and rated as poor, moderate, and good. In addition, attitude of the volunteers and preparedness of Mahabad Red Crescent Society was rated as inappropriate and appropriate using a questionnaire.
Results: The mean age of volunteers was Only 1 0. Conclusion: The findings of the present study showed poor knowledge and inappropriate attitude of Mahabad Red Crescent Society volunteers in encountering probable bioterrorist attacks. Furthermore, the Red Crescent Society of this town had an inappropriate level of preparedness in the field of bioterrorism from the viewpoint of the studied volunteers. To present our experiences in understanding and minimizing bowtie-filter crescent artifacts and bowtie-filter normalization artifacts in a clinical cone beam computed tomography system.
Bowtie-filter position and profile variations during gantry rotation were studied. Two previously proposed strategies A and B were applied to the clinical cone beam computed tomography system to correct bowtie-filter crescent artifacts. Physical calibration and analytical approaches were used to minimize the norm phantom misalignment and to correct for bowtie-filter normalization artifacts. A combined procedure to reduce bowtie-filter crescent artifacts and bowtie-filter normalization artifacts was proposed and tested on a norm phantom, CatPhan, and a patient and evaluated using standard deviation of Hounsfield unit along a sampling line.
The bowtie-filter exhibited not only a translational shift but also an amplitude variation in its projection profile during gantry rotation. Strategy B was better than strategy A slightly in minimizing bowtie-filter crescent artifacts, possibly because it corrected the amplitude variation, suggesting that the amplitude variation plays a role in bowtie-filter crescent artifacts.
The physical calibration largely reduced the misalignment-induced bowtie-filter normalization artifacts, and the analytical approach further reduced bowtie-filter normalization artifacts. The combined procedure minimized both bowtie-filter crescent artifacts and bowtie-filter normalization artifacts, with Hounsfield unit standard deviation being The combined procedure also demonstrated reduction of bowtie-filter crescent artifacts and bowtie-filter normalization artifacts in a CatPhan and a patient.
We have developed a step. Crescentic glomerulonephritis GN is a devastating disease with rapidly progressive deterioration in kidney function, which, histologically, manifests as crescent formation in most glomeruli. Herein, we elucidated sequential events and cellular and molecular interactions occurring during crescentic lesion onset and evolution.
By analyzing kidney biopsy specimens of patients with extracapillary GN, divided according to the grade of glomerular lesions, we found that the accumulation of macrophages expressing matrix metalloproteinase started manifesting in glomeruli affected by early-stage lesions, whereas AT 1 receptor expression could not be detected. In glomeruli with advanced lesions, AT 1 receptor expression increased markedly, and the up-regulation of SDF-1, and its receptor C-X-C chemokine receptor 7, was documented on podocytes and PECs, respectively.
The present findings support the possibility that angiotensin-converting enzyme inhibitor treatment might limit PEC activation and reduce the frequency and extension of crescents in extracapillary GN. Ischemia-induced glomerular parietal epithelial cells hyperplasia: Commonly misdiagnosed cellular crescent in renal biopsy.
Ischemic pseudo-cellular crescent IPCC that is induced by ischemia and composed of hyperplastic glomerular parietal epithelial cells resembles cellular crescent. In this study, we aimed to assess the clinical and pathological features of IPCC in renal biopsy to avoid over-diagnosis and to determine the diagnostic basis.
Appropriate clinical data, morphology, and immunohistochemical features of all cases were retrieved. Results showed that the basement membrane of glomerulus with IPCC appeared as a concentric twisted ball, and glomerular cells of the lesion were reduced even entirely absent, and the adjacent afferent arterioles showed sclerosis or luminal stenosis. Furthermore, immune globulin deposition, vasculitis, and fibrinous exudate have not been observed in IPCC.
While the cellular crescents showed diverse characteristics in both morphology and immunostaining in the control group. Therefore, these results indicated that IPCC is a sort of ischemic reactive hyperplasia and associated with sclerosis, stenosis, or obstruction of adjacent afferent arterioles, which is clearly different from cellular crescents result from glomerulonephritis. Long-term statistics of extreme tsunami height at Crescent City. Historically, Crescent City is one of the most vulnerable communities impacted by tsunamis along the west coast of the United States, largely attributed to its offshore geography.
Trans-ocean tsunamis usually produce large wave runup at Crescent Harbor resulting in catastrophic damages, property loss and human death. How to determine the return values of tsunami height using relatively short-term observation data is of great significance to assess the tsunami hazards and improve engineering design along the coast of Crescent City.
In the present study, the extreme tsunami heights observed along the coast of Crescent City from to are fitted using six different probabilistic distributions, namely, the Gumbel distribution, the Weibull distribution, the maximum entropy distribution, the lognormal distribution, the generalized extreme value distribution and the generalized Pareto distribution.
The maximum likelihood method is applied to estimate the parameters of all above distributions. Both Kolmogorov-Smirnov test and root mean square error method are utilized for goodness-of-fit test and the better fitting distribution is selected.
Assuming that the occurrence frequency of tsunami in each year follows the Poisson distribution, the Poisson compound extreme value distribution can be used to fit the annual maximum tsunami amplitude, and then the point and interval estimations of return tsunami heights are calculated for structural design. The results show that the Poisson compound extreme value distribution fits tsunami heights very well and is suitable to determine the return tsunami heights for coastal disaster prevention.
Renal progenitors localized to the inner surface of Bowman's capsule can regenerate podocytes, but whether dysregulated proliferation of these progenitors contributes to crescent formation is unknown. Taken together, these results suggest that glomerular hyperplastic lesions derive from the proliferation of renal progenitors at different stages of their differentiation toward mature podocytes, providing an explanation for the pathogenesis of hyperplastic lesions in podocytopathies and crescentic glomerulonephritis.
Agriculture in the Fertile Crescent : Continuity and change under climate change. The Fertile Crescent is a highly biodiverse region where most temperate-zone agricultural species originated and were first domesticated. A favorable environment, a special plant community, and an adaptive population combined to initiate the transition from a hunter-gatherer economy to one based on These analysts attribute this change in behavior to the length of time it can take to An idealised study for the long term evolution of crescentic bars.
An idealised study that identifies the mechanisms in the long term evolution of crescentic bar systems in nature is presented. Growth to finite amplitude i. These nonlinear effects are added to a linear stability model and used to predict crescentic bar development along a beach in Duck, North Carolina USA over a 2-month period. The equilibration prolongs the development of bed patterns, thus allowing the long term evolution.
Higher harmonic interaction enables the amplitude to be transferred from longer to shorter lengthscales, which leads to the dominance of shorter lengthscales in latter post-storm stages, as observed at Duck. The comparison with observations indicates the importance of higher harmonic interaction in the development of nearshore crescentic bar systems in nature.
Additionally, it is concluded that these nonlinear effects should be included in models simulating the development of different bed patterns, and that this points a way forward for long-term morphodynamical modelling in general. Proliferative, necrotizing and crescentic immune complex-mediated glomerulonephritis in a cat. Azotemia, hyperphosphatemia and hypoalbuminemia were the main biochemical findings. Serial analyses of the urine revealed isosthenuria, proteinuria and eventual glucosuria.
Hyperechoic perirenal fat was detected surrounding the right kidney by ultrasonography. Histopathologic evaluation of ante-mortem ultrasound-guided needle biopsies of the right kidney was consistent with proliferative, necrotizing and crescentic glomerulonephritis with fibrin thrombi, proteinaceous and red blood cell casts, and moderate multifocal chronic-active interstitial nephritis.
Owing to a lack of clinical improvement, the cat was eventually euthanized. Post-mortem renal biopsies were processed for light microscopy, transmission electron microscopy and immunofluorescence. This revealed severe focal proliferative and necrotizing glomerulonephritis with cellular crescent formation, podocyte injury and secondary segmental sclerosis.
Severe diffuse acute tubular epithelial injury and numerous red blood cell casts were also seen. Relevance and novel information To our knowledge, this is the first report of naturally occurring proliferative, necrotizing and crescentic immune complex glomerulonephritis in a cat. Effects of the reconnection electric field on crescent electron distribution functions in asymmetric guide field reconnection.
In asymmetric reconnection with a guide field in the Earth's magnetopause, electron motion in the electron diffusion region EDR is largely affected by the guide field, the Hall electric field, and the reconnection electric field. The electron motion in the EDR is neither simple gyration around the guide field nor simple meandering motion across the current sheet.
The combined meandering motion and gyration has essential effects on particle acceleration by the in-plane Hall electric field existing only in the magnetospheric side and the out-of-plane reconnection electric field. We analyze electron motion and crescent -shaped electron distribution functions in the EDR in asymmetric guide field reconnection, and perform 2-D particle-in-cell PIC simulations to elucidate the effect of reconnection electric field on electron distribution functions.
Recently, we have analytically expressed the acceleration effect due to the reconnection electric field on electron crescent distribution functions in asymmetric reconnection without a guide field Bessho et al. Plasmas, 24, , We extend the theory to asymmetric guide field reconnection, and predict the crescent bulge in distribution functions.
The time period is expressed as a hybrid of the meandering period and the gyro period. Due to the guide field, electrons not only oscillate along crescent -shaped trajectories in the velocity plane perpendicular to the antiparallel magnetic fields, but also move along parabolic trajectories in the velocity plane coplanar with magnetic field. The trajectory in the velocity space gradually shifts to the acceleration direction by the reconnection electric field as multiple bounces continue.
Due to the guide field, electron distributions for meandering particles are bounded by two paraboloids or hyperboloids in the. Motor carrier case study evaluation report : appendix C, Vol. The Crescent Project element of the HELP Program is a bi-national multi-jurisdictional : cooperative research and demonstration initiative involving the public and private sectors in an : application of advanced technologies for the creation of an in Four out of ten patients were anuric and needed dialysis treatment at the start of treatment.
Therapeutic benefit, i. It is difficult to establish whether the better therapeutic results in the more recently treated group were due to PE or to MP pulses of to both the new approaches, even though the clinical improvement obtained in all the 3 patients treated with PE without concomitant MP suggest a specific beneficial role for PE. RPCGN is a catastrophic illness characterized by progressive deterioration of kidney function, resulting in oliguria and uremia, usually within weeks or months.
The most consistent histopathologic finding is the presence of extensive glomerular crescents resulting from proliferation of the extracapillary epithelial cell lining of Bowman's capsule. Most studies that have assessed the predictors of recurrent IgA nephropathy IgAN in the renal allograft have focused on post-transplant features. Identifying high-risk pre-transplant features of IgAN is useful for counseling patients and may help in tailoring post-transplant immunosuppression.
We investigated the pre-transplant clinical and biopsy features of 62 patients with IgAN who received transplants at Columbia University Medical Center from to and compared the characteristics and outcomes of patients with IgAN recurrence to those without recurrence. The primary outcome was time to recurrent IgAN. Secondary outcomes were a composite of doubling of creatinine or allograft failure, and recurrent IgAN as a cause of allograft dysfunction. Of the 62 patients, 14 had recurrent IgAN in the allograft.
Mean time to recurrence was 2. Those with recurrent disease were younger at the time of native kidney biopsy 29 vs. Features of native IgAN can help predict the risk of recurrent disease in the renal allograft. In particular, immunologically active disease represented by earlier age of onset and greater burden of crescents on native biopsy is more likely to recur after transplant.
Karger AG, Basel. Formation of tight junctions between neighboring podocytes is an early ultrastructural feature in experimental crescentic glomerulonephritis. However, the sequential changes in glomerular ultrastructure in CGN are not well defined. This study investigated the time course of glomerular ultrastructure in experimental CGN. Methods: Transmission electron microscopy TEM was performed using kidney samples from rats with nephrotoxic serum nephritis NSN from day 1 to day Morphometric analysis was conducted on randomly selected glomeruli captured on TEM digital images.
Results: On day 1 of NSN, there was widespread formation of focal contacts between the cell bodies of neighboring podocytes, and tight junctions were evident at the site of cell-to-cell contact. This was confirmed by the increased expression of the tight junction molecule, zonula occludens-1 ZO-1, which localized to the points of podocyte cell—cell body contact.
On day 2, the interpodocyte distance decreased and the glomerular basement membrane thickness increased. Fibrinoid necrosis and cellular crescents were evident in all glomeruli by days 7 and In vitro, the exposure of podocytes to macrophage-conditioned media altered cellular morphology and caused an intracellular redistribution of ZO Conclusion: The formation of tight. Crescent shaped Fabry-Perot fiber cavity for ultra-sensitive strain measurement.
Optical Fabry-Perot interferometer sensors based on inner air-cavity is featured with compact size, good robustness and high strain sensitivity, especially when an ultra-thin air-cavity is adopted. The typical shape of Fabry-Perot inner air-cavity with reflection mode of operation is elliptic, with minor axis along with and major axis perpendicular to the fiber length. The first reflection surface is diverging whereas the second one is converging.
To increase the visibility of the output interference pattern, the length of major axis should be large for a given cavity length. However, the largest value of the major axis is limited by the optical fiber diameter. If the major axis length reaches the fiber diameter, the robustness of the Fabry-Perot cavity device would be decreased.
Here we demonstrate an ultra-thin crescent shaped Fabry-Perot cavity for strain sensing with ultra-high sensitivity and low temperature cross-sensitivity. The crescent -shape cavity consists of two converging reflection surfaces, which provide the advantages of enhanced strain sensitivity when compared with elliptic or D-shaped FP cavity. The device is fabricated by fusion splicing an etched multimode fiber with a single mode fiber, and hence is simple in structure and economic in cost.
Urinary Transforming Growth Factor-beta 1 as a marker of response to immunosuppressive treatment, in patients with crescentic nephritis. Full Text Available Abstract Background Crescentic nephritis is characterized by formation of cellular crescents that soon become fibrotic and result in irreversible damage, unless an effective immunosuppressive therapy is rapidly commenced. Methods Fifteen patients with crescentic nephritis were included in the study.
Twelve patients with other types of proliferative glomerulonephritis and ten healthy subjects were used as controls. Results Improvement of renal function with immunosuppressive therapy was observed in 6 and stabilization in 4 patients serum creatinine from 3. In 5 patients, with severe impairment of renal function who started on dialysis, no improvement was noted. The main histological feature differentiating these 5 patients from others with improved or stabilized renal function was the percentage patients with poor response to treatment were the percentage of glomeruli with crescents and the presence of ruptured Bowman's capsule and glomerular necrosis.
Clinical features and outcomes of ANCA-associated renal vasculitis. Full Text Available To determine the patterns and outcomes of the pauci-immune vasculitis in the nephrology department at hospital La Conception in Marseille, we conducted a retrospective study including all patients with diagnosis of pauci-immune renal vasculitis between January 1, and December 31, The median age of the patients was The mean serum creatinine at admission was 3. Two patients with WG received plasmapheresis and seven patients required emergency hemodialysis.
Induction therapy comprised cyclophosphamide IV and corticosteroids, while maintenance therapy included azathioprine for the majority of patients. Eighty four percent of the patients experienced complete remission after induction therapy. After 35 months of follow-up, eight patients ended on chronic hemodialysis, and five patients died. ANCA associated vasculitis are frequent in our patients. The bony crescent sign - a new sign of facial nerve schwannoma.
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Atlanta lost its first three games of a four-game homestand before beating the Toronto Raptors as 1-point home underdogs Saturday. Two of those losses were to the top two seeds of the West—Utah Jazz and Los Angeles Lakers—with the other coming against Dallas this past Wednesday.
ET tip-off. Lines last updated at p. Tip-off will be at 7 p. Toronto is on the road swing thus far and will wrap it up Thursday against the Boston Celtics. The Raps beat the Memphis Grizzlies Monday and covered the spread with ease as 3-point favorites. They're also against the spread on this trip. Please enter an email address. Something went wrong. Against the spread ATS I could see Kawhi picking up the slack offensively while PG13 is out of the lineup, and that task is certainly made easier going against the Kings who have the worst defensive rating in the Association.
Milwaukee Bucks at Phoenix Suns odds, picks and prediction. Charlotte Hornets at Memphis Grizzlies odds, picks and prediction. February 7, From The Web Ads by Zergnet. Washington is straight up and ATS in Share this article share. Also see: Bank on these Tom Brady prop bets. He caught 13 of 15 targets and went for a season-high yards and 3 touchdowns in a road win for the Chiefs. Also see: Bank on these Tyreek Hill prop bets. Place all of your legal, online sports bets at BetMGM! Bet on the Big Game now!
Terms and conditions apply. Bet on the Bucs now! Mathieu had five combined tackles and an interception in the Week 12 meeting against the Bucs. Another pick or fumble recovery and a defensive score at a pivotal point in the game could award the Honey Badger. JPP led the team with 9. New to sports betting? Want action on NFL bets? Sign up and bet at BetMGM. Follow Esten McLaren on Twitter.
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